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KMID : 0043320160390060771
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Archives of Pharmacal Research
2016 Volume.39 No. 6 p.771 ~ p.777
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Two new ursane-type triterpenoid saponins from Elsholtzia bodinieri
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Zhong Jin Dong
Zhao Xue Wei
Chen Xuan Qin
Li Hong Mei
Chen Chin Ho
Xia Xue Shan
Li Rong Tao
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Abstract
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Two new ursane-type triterpenoid saponins, bodiniosides M (1) and N (2), along with three known saponins, oblonganosides I (3), pseudobuxussaponin B (4) and bodinioside A (5), were isolated from the aerial parts of Elsholtzia bodinieri. The structures of compounds 1 and 2 were characterized by spectroscopic data as well as acid hydrolysis and GC analysis as 3-O-β-d-xylopyranosyl-19α-hydroxy-23-acetoxy-urs-12(13)-en-28-oic acid 28-O-α-l-rhamnopyranosyl-(1-2)-β-d-glucopyranoside and 3-O-β-d-glucopyranosyl-2α,19α-dihydroxy-urs-12(13)-en-28,20β-lactone. Compounds 1 and 5 exhibited potent anti-HCV activities in vitro with a selective index of 6.53 and 4.41, respectively.
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KEYWORD
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Elsholtzia bodinieri, Labiatae, Ursane-type triterpenoid, Saponins, Anti-HCV activities
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